Among the more than 100 recombinant proteins produced by engineered Y. lipolytica [202], there are several pharmaceutically important human-compatible bio-compounds secreted by ‘humanized’ strains, including interferon alpha 2b [203], epidermal growth factor [204], N-glycoproteins [205,206], blood coagulation factor XIIIa [207], proinsulin and insulinotropin [208], cytochrome P450 [209], estrogen receptor α [210], and anaphylatoxin C5a that possesses both spasmogenic and leukocyte-related properties [211].
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